Neurodegenerative diseases such as Alzheimer`s are among the most puzzling in medical research.
Ramon Velazquez Lead author Ramón Velázquez is a researcher with the ASU-Banner Neurodegenerative Disease
The Translational Genomics Research Institute (TGen) investigate the consequences of glyphosate exposure on the brain of mice in a new study
However, when TNF-α levels are dysregulated, a number of diseases related to neuroinflammation can occur.
Jane Winstone First author Joanna Winstone is a researcher with the ASU-Banner Neurodegenerative Disease Research Center and the ASU College of Life Sciences.
The study further demonstrates in cell culture studies that glyphosate exposure appears to increase the production of soluble beta-amyloid (Aβ) and reduce the viability of neurons.
These cells, known as oligodendrocytes, are affected by elevated levels of TNF-α.
''We found increases in TNF-α in the brain after exposure to glyphosate," says Velázquez.
"While we examined the pathology of AD, this could have implications for many neurodegenerative diseases