Globally, there are approximately 55 million people with dementia

 the incidence of the disease has been steadily increasing.

Epidemiological studies have shown a correlation between the temporal distribution of energy intake during a day (TPEI) 

the risk of several chronic diseases such as diabetes and hypertension.

Previous studies in animal models have shown that disruption in meal timing can cause disturbances in clock rhythms in the hippocampus

However, long-term studies on IPDs and cognitive function are lacking.

 The result showed that compared with those with an "evenly distributed" pattern

 long-term cognitive function scores were significantly lower in those with unbalanced TPEI

maintaining a balanced TPEI has potentially positive effects on cognitive health,